The increasing micronutrient deficiency within the nutritional habits of the world’s population and the growing need for healthy foods have given rise to the development of biofortified crops. In a context where the consumer’s attention is focused on a healthy lifestyle and respect for the environment, the cultivation of potatoes enriched with selenium offers an undisputed advantage in the pursuit of this twofold objective. The crop has been analyzed through the life-cycle assessment (LCA) methodology in order to highlight the environmental burden generated by selenium (Se) potato cultivation and to compare it with potato in conventional regime. The LCA highlights how the biofortified product is more sustainable than the conventional one, and this not only provides a benefit for the consumer, but also designates a new time for farmers who have the opportunity to implement more environmentally friendly practices.