This work presents the results of long-term deep-water observations carried out in the southwestern Adriatic margin. Hydrodynamics and thermohaline measurements were carried out in the last 100 m of the water column using two long-term moorings placed at two different locations along the western sector of the Adriatic continental margin (open slope vs. submarine canyon). The observations, carried out over a period of almost 10 years, made it possible to define the intra- and interannual deep-water dynamics, which are mainly influenced by the passage of cold, dense water. The hydrodynamic field is influenced by seasonal behavior and varies from year to year, with no clear temporal trend or periodicity. Thermohaline properties follow hydrodynamics but also show a climatological trend toward higher temperatures and salinity. The combination and variability of preconditioning factors explains the interannual variability in dense water passage at the mooring sites triggering the formation of dense water in the northern Adriatic. The impulsive nature of the dense water flow, which is difficult to capture with sporadic oceanographic surveys, and its linkage with the large-scale atmospheric circulation make continuous monitoring essential to answer open questions about cascading processes and deep-water dynamics under a global change scenario.