Climate change causes are becoming an increasingly persistent challenge for the country’s agri-food sector. The results of agricultural activities vary according to the impact of climate change. The agricultural producers are looking for new solutions to adapt to the respective challenges and to identify the models of stability of the level of production or even to increase it under these conditions. The soil tillage technology recommended by a large part of the well-known scientists in the field is the no till technology that today in the Republic of Moldova is at a stage of knowledge and experiment. In the application of this technology a role is played by the use of plant protection products and their profitability in relation to the economic results. This paper presents a comparative study of the application of plant protection products in the no till technology compared to the traditional one. This work is due to the increasing interest that has been emerging lately with this technology from farmers regarding its reasoning.