Found an issue? Give us feedback

Arzneimittelforschun...arrow_drop_down

Arzneimittelforschung

Article . 1976

Data sources: Europe PubMed Central

Select content type to embed

All Research products

arrow_drop_down

<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

[Pharmacokinetic studies on absorption and excretion of oxazepam in Combination with alcohol (author's transl)].

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1976 German Journal:Arzneimittel-Forschung, volume 25 (issn: 0004-4172,

Authors: H J, Mallach; A, Moosmayer; K, Gottwald; M, Staak;

pmid: 1106447

[Pharmacokinetic studies on absorption and excretion of oxazepam in Combination with alcohol (author's transl)].

- Summary
- Subjects
- Related research
  (1)
- Metrics

Abstract

The influence of 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl 2H-1,4-benzodiazepin-2-one (oxazepam, Adumbran) (30 mg) on the effects produced by alcohol (0.75 g/kg) and vice versa was studied in 14 male test subjects using the following scheme: (A) alcohol; (B) placebo; (C) oxazepam; (D) oxazepam and alcohol combined; (E) alcohol given 30 min prior to oxazepam. Blood and serum levels were determined and excretion in the urine was tested during the 7-h duration of the experiment. The blood alcohol curves show a similar course, leading to the conclusion that oxazepam has no influence on the elimination of alcohol. Alcohol retrads the intestinal absorption of oxazepam but, on the other hand, does not show an effect on the specific metabolism of oxazepam.

Keywords

Adult, Male, Clinical Trials as Topic, Chromatography, Gas, Time Factors, Dose-Response Relationship, Drug, Ethanol, Oxazepam, Intestinal Absorption, Humans, Drug Interactions

1 Research products, page 1 of 1

Retrading in market games
2004IsAmongTopNSimilarDocuments

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	14
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average