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Allergologia et Immu...arrow_drop_down

Allergologia et Immunopathologia

Article . 1986

Data sources: Europe PubMed Central

Archivio istituzionale della ricerca - Università di Padova

Article . 1985

Data sources: Archivio istituzionale della ricerca - Università di Padova

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Reliability of salivary theophylline concentration monitoring in children with bronchial asthma following the administration of different drug formulations.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1985 Italy English Journal:Allergologia et immunopathologia, volume 13 (issn: 0301-0546,

Authors: Boner AL; Valletta EA; PLEBANI, MARIO; Biancotto R; Bellanti JA;

pmid: 4083233

handle: 11577/2509031

Reliability of salivary theophylline concentration monitoring in children with bronchial asthma following the administration of different drug formulations.

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Abstract

The applicability and reliability of the clinical usefulness of monitoring salivary theophylline concentrations as a predictive measure of serum concentrations was evaluated in a total of 59 children with asthma, divided in four groups. Three pharmacological preparations of oral theophylline (aqueous, alcoholic and slow release) were evaluated after single administration (groups 1-3); slow release theophylline was also tested in a steady state of metabolism in children under chronic therapy with the drug (group 4). Although a good correlation between theophylline concentrations in serum and saliva was observed in each group, the wide range of variability in serum levels predicted from salivary levels (20-60%) appears to limit the usefulness of this approach. The salivary measurements of theophylline may be useful as a general guide in management of patients, or in assessment of compliance.

Country

Italy

Related Organizations

University of Padua
Italy

Keywords

Adolescent, Ethanol, Water, Asthma, Solutions, Theophylline, Child, Preschool, Delayed-Action Preparations, Humans, Patient Compliance, Child, Saliva

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