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Biomeditsinskaya Khi...arrow_drop_down

Biomeditsinskaya Khimiya

Article . 2004

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[Hepatoprotective effects of amino acids with branched hydrocarbon chains and taurine in experimental subchronic alcohol intoxication and ethanol withdrawal].

descriptionPublicationkeyboard_double_arrow_right Article 02 Jul 2004 Russian Journal:Biomeditsinskaia khimiia, volume 50 (issn: 2310-6972,

Authors: Iu E, Razvodovskiĭ; E M, Doroshenko; N I, Prokopchik; V Iu, Smirnov; S Iu, Ostrovskiĭ;

pmid: 15108628

[Hepatoprotective effects of amino acids with branched hydrocarbon chains and taurine in experimental subchronic alcohol intoxication and ethanol withdrawal].

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Abstract

Forced alcoholization of rats according to Majchrowicz led to the development of fatty liver. The subsequent ethanol withdrawal was accompanied by amino acid imbalance in the pool of free sulfur-containing and glycogenic amino acids in liver and blood plasma. Similar changes were observed after prolonged alcohol intoxication. Intragastric administration of the amino acid composition containing branched-chain amino acids and taurine corrected the amino acid imbalance and reduced the development of the steatosis of the liver.

Keywords

Ethanol, Taurine, Rats, Substance Withdrawal Syndrome, Fatty Liver, Liver, Animals, Amino Acids, Rats, Wistar, Alcoholic Intoxication

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