CNS activities of ethanol extract of aerial parts of Hygrophila difformis in mice.
Copyright policy )CNS activities of ethanol extract of aerial parts of Hygrophila difformis in mice.
The ethanol extract of aerial parts of Hygrophila difformis (EEHD) was tested for possible pharmacological effects on experimental animals. EEHD significantly potentiated the sleeping time of mice induced by standard hypnotics, viz. pentobarbital sodium, diazepam, and meprobamate in a dose dependent manner. EEHD showed significant analgesic properties as evidenced by the significant reduction in the number of writhes and stretches induced in mice by 1.2% acetic acid solution. It also potentiated analgesia induced by morphine and pethidine in mice. Pretreatment with EEHD caused significant protection against strychnine and leptazol-induced convulsions. The behavioral studies on mice indicate CNS depressant activity of the ethanol extract of H. difformis.
Central Nervous System, Male, Pain Threshold, Pain, Lethal Dose 50, Mice, Acanthaceae, Animals, Hypnotics and Sedatives, Acetic Acid, Analgesics, Behavior, Animal, Dose-Response Relationship, Drug, Ethanol, Central Nervous System Depressants, Plant Components, Aerial, Disease Models, Animal, Pentylenetetrazole, Anticonvulsants, Female
Central Nervous System, Male, Pain Threshold, Pain, Lethal Dose 50, Mice, Acanthaceae, Animals, Hypnotics and Sedatives, Acetic Acid, Analgesics, Behavior, Animal, Dose-Response Relationship, Drug, Ethanol, Central Nervous System Depressants, Plant Components, Aerial, Disease Models, Animal, Pentylenetetrazole, Anticonvulsants, Female
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