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Therapies

Article . 2012

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[Disulfiram and addiction: reminders and new perspectives of use].

descriptionPublicationkeyboard_double_arrow_right Article 11 Dec 2012 French Journal:Therapie, volume 66 (issn: 0040-5957,

Authors: Thomas, Charpeaud; Julie, Geneste; Jeannot, Schmidt; Pierre-Michel, Llorca; Georges, Brousse;

pmid: 21924121

[Disulfiram and addiction: reminders and new perspectives of use].

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Abstract

Disulfiram is a relatively old molecule, which today remains marginal in the treatment of alcoholics diseases. Using this type of treatment is the subject of ethical debate. The prescription of this therapeutic requires clinical and biological rigorous evaluations before treatment. Its main action in treatment of alcoholism is related to the restraint of acetaldehyde dehydrogenase action causing the antabuse reaction. Prescription of disulfiram, supported by specialized programs of compartmental integrated care, brings significant benefit for alcoholic patients. Recently, following the discovery of its action on dopamine metabolism, disulfiram has been a renewed interest in the treatment of addictions to cocaine and pathological gambling. Although current data are insufficient to generalize its use in routine practice, they constitute a line of research interest for the future.

Keywords

Drug Implants, Ethanol, Substance-Related Disorders, Dopamine, Central Nervous System Depressants, Alcoholism, Disulfiram, Gambling, Humans, Alcohol Deterrents

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	7
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