This data set is linked to a study that sought to investigate the impacts of long-term ocean acidification on the olfactory rosette transcriptome of the European sea bass (Dicentrarchus labrax) and on viral resistance. We exposed two generations of the D. labrax to end-of-century predicted pH levels (IPCC RCP8.5), with parents being exposed for 53 months (F1) and their offspring for 18 months (F2). Our design included a transcriptomic analysis of the olfactory rosette (collected from the F2) and a viral challenge (exposing F2 to betanodavirus) where we assessed survival rates. This data set contains physico-chemical parameters of the rearing sea water including the carbonate system components as well as survival data and temperature measurements during the viral challenge. The rearing periods extends as follows: F1 parents: 24 October 2013 - 26 March 2018; in duplica tanks per treatment F2 eggs phase: 27 March 2018 - 31 March 2018; in a simplica per treatment F2 larval phase: 1 April 2018 – 1 June 2018; in triplica tanks per treatment F2 juvenile phase: 2 April 2018 – 17 October 2019; in a duplica per treatment However, since this study extends over 7 years, some data is not available in digital form but in paper form. Therefore, here we provide digitalized data for the following periods. F1 parents: 8 February 2016 - 6 March 2018; monthly data showing physico-chemical and carbonate parameters of the sea water F2 eggs phase: 27 March 2018 - 31 March 2018; daily data showing the pH and temperature of the sea water F2 larval phase: 1 April 2018 – 1 June 2018; monthly data showing physico-chemical and carbonate parameters of the sea water and daily data showing the pH and temperature of the sea water F2 juvenile phase: 2 April 2018 – 24 October 2018; daily data showing the pH and temperature of the sea water F2 juvenile phase: 2 April 2018 – 11 February 2019; monthly data showing physico-chemical and carbonate parameters of the sea water pH in NIST scale and temperature were daily measured with a WTW 3110 pH meter (Xylem Analytics Germany, Weilheim, Germany; with electrode: WTW Sentix 41) calibrated daily with pH4.0 and pH7.0 buffers (WTW, Germany). Total alkalinity was measured following the adapted protocol of Strickland and Parsons: a 50 ml sample of filtered tank seawater was mixed with 15 ml HCl (0.01 M) and pH was measured immediately. The software CO2SYS using the constants from Mehrbach et al. refitted by Dickson and Millero were used to calculate pH in NIST scale to total scale and the carbonate chemistry components.