<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Macrophage inflammatory protein-1 ? regulates prostaglandin e and lnterleukin-6 production by human gestational tissues in vitro

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jan 1996 Australia Publisher:Springer Science and Business Media LLCJournal:Journal of the Society for Gynecologic Investigation, volume 3, pages 12-16 (issn: 1071-5576,

Authors: Dudley, Donald J.; Edwin, Samuel S.; Mitchell, Murray D.;

doi: 10.1016/1071-5576(95)00042-9 , 10.1177/107155769600300103

Macrophage inflammatory protein-1 ? regulates prostaglandin e and lnterleukin-6 production by human gestational tissues in vitro

- Summary
- Subjects
- Related research
  (1)
- Metrics

Abstract

To determine if the inflammatory cytokine macrophage inflammatory protein-1α (MIP-1α) stimulates the production of prostaglandin E2 (PCE2) and interleukin-6 (IL-6) by human gestational tissues. Human decidual cells, chorion cells, and amnion cells were isolated from term placentas of women with normal pregnancies, and primary cultures of each cell line were established. In various concentrations, MIP-1α was then applied to each cell culture for 16 hours at 37 C, and culture supematants were assayed for PGE2 and IL-6. After incubation with MIP-1α, decidual cells produced increased amounts of IL-6 (P < .05) but not PGE2. When subjected to similar conditions, chorion cells produced increased amounts of both IL-6 and PGE2 (P < .05). Conversely, amnion cells produced increased amounts of only PGE2 in response to increasing concentrations of MIP-1α (P < .05). Maternal and fetal gestational tissues differentially respond to MIP-1α with regard to PGE2 and IL-6 production; MIP-1α may play a role in both the initiation and propagation of the inflammatory response associated with intrauterine infection.

Country

Australia

Related Organizations

Keywords

Interleukin-6, Preterm Labor, Cells, Parturition, Prostaglandin E(2), 1103 Clinical Sciences, Human Amnion, Biosynthesis, Macrophage inflammatory protein-1 alpha, Primary Culture, Cytokines, 1114 Paediatrics and Reproductive Medicine, Infection, Human Chorion Laeve, Tumor-necrosis-factor

1 Research products, page 1 of 1

Fimbriation of Pseudomonas cepacia
1992IsAmongTopNSimilarDocuments

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	13
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average