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Homeostasis as Regulated by Activated Macrophage. VI. Protective Effect of LPSw (a Lipopolysaccharide from Wheat Flour) against Acute Infection by Toxoplasma gondii in Mice.

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jan 1992Publisher:Pharmaceutical Society of JapanJournal:Chemical and Pharmaceutical Bulletin, volume 40, pages 1,266-1,267 (issn: 0009-2363, eissn: 1347-5223,

Authors: Akio Kobayashi; Takashi Nishizawa; Gen-Ichiro Soma; Hiroyuki Inagawa; Yasuhiro Suzuki; Akinobu Morikawa; Den'ichi Mizuno;

doi: 10.1248/cpb.40.1266

pmid: 1394645

Homeostasis as Regulated by Activated Macrophage. VI. Protective Effect of LPSw (a Lipopolysaccharide from Wheat Flour) against Acute Infection by Toxoplasma gondii in Mice.

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Abstract

An oral administration of partially purified LPSw, a lipopolysaccharide (LPS) from wheat flour, at a concentration of 20 ng/ml in drinking water beginning 1d after infection significantly decreased mouse mortality and prevented animal weight loss in acute infection with Toxoplasma gondii. Whereas 71% (5/7) of mice in a control group that did not receive LPSw died of toxoplasmosis, only 14% (1/7) of mice treated with LPSw died (p less than 0.05). The administration of LPS purified from Bordetella pertussis also significantly decreased the mortality of infected mice. LPS from Escherichia coli and synthetic lipid A (LA-15-PP(506)), however, did not show a significant decrease in mortality.

Related Organizations

Jikei University School of Medicine
Japan
Jikei University School of Medicine
Japan

Keywords

Lipopolysaccharides, Mice, Inbred BALB C, Macrophages, Administration, Oral, Macrophage Activation, Mice, Toxoplasmosis, Animal, Acute Disease, Animals, Homeostasis, Female, Toxoplasma, Triticum

8 Research products, page 1 of 1

Homeostasis as Regulated by Activated Macrophage. IV. Analgesic Effect of LPSw, a Lipopolysaccharide of Wheat Flour.
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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	18
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	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average