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Journal of Child Psychology and Psychiatry
Article . 2017 . Peer-reviewed
License: Wiley Online Library User Agreement
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Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents

Authors: Tianye Jia; Robert Whelan; Hugh Garavan; Hugh Garavan; Georgy Bakalkin; Tomáš Paus; Tomáš Paus; +31 Authors

Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents

Abstract

BackgroundNociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome‐wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol‐use disorders.MethodsHere, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen‐year‐old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol‐preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity.ResultsWe found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens.ConclusionsOur findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse.

Countries
Italy, Ireland
Keywords

Male, Adolescent, 150, 610, ALCOHOL-ABUSE, Underage Drinking, Nociceptin Receptor, Binge Drinking, Epigenesis, Genetic, PSYCHOLOGICAL STRESS, Reward, Animals, Humans, ENVIRONMENTAL STRESS, DNA Methylation, Anticipation, Psychological, Magnetic Resonance Imaging, Rats, Health, Receptors, Opioid, Ventral Striatum, Genes & Society, Female, GENETIC RISK FACTOR, Stress, Psychological, Neuroscience

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    Top 10%
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
12
Top 10%
Average
Top 10%
Green
bronze