Global climate change will affect the viability and spread of zoonotic parasites, while agricultural land use changes will influence infection sources and reservoirs. The health impact of these environmental changes will depend on the social, economic and physical resilience of the population. This review describes the influence of climatic variability, land-use changes, and social factors on cryptosporidiosis and giardiasis in humans. Global to public health to individual-level interventions to reduce future disease burden are highlighted. Because future environmental change is expected to have the greatest health impacts in countries with limited resources, increasing research and adaptation capabilities in these regions is emphasized. Understanding how environmental and social processes interact to influence disease transmission is essential for the development of effective strategies for disease prevention.