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Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances

Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hormones, antagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat absorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs. We provide insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored.
- Max Planck Institute of Neurobiology Germany
- Max Planck Society Germany
- Helmholtz Association of German Research Centres Germany
- Helmholtz Zentrum München Germany
- University Hospital Leipzig Germany
obesity, Anti-obesity Drugs ; Diabetes Mellitus ; Energy Balance ; Obesity ; Obesity Metabolism, anti-obesity drugs, Review, energy balance, Microbiology, QR1-502, pharmacology_toxicology, obesity metabolism, Risk Factors, diabetes mellitus, Diabetes Mellitus, Humans, Anti-Obesity Agents, Obesity, Energy Metabolism
obesity, Anti-obesity Drugs ; Diabetes Mellitus ; Energy Balance ; Obesity ; Obesity Metabolism, anti-obesity drugs, Review, energy balance, Microbiology, QR1-502, pharmacology_toxicology, obesity metabolism, Risk Factors, diabetes mellitus, Diabetes Mellitus, Humans, Anti-Obesity Agents, Obesity, Energy Metabolism
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).57 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
