Use of productivity-enhancing technologies (PET: growth hormones, ionophores, and beta-adrenergic agonists) to improve productivity has recently garnered public attention regarding environmentally sustainability, animal welfare, and human health. These consumer perceptions and increased demand for PET-free beef offer opportunities for the beef industry to target niche premium markets, domestically and internationally. However, there is a need to critically examine the trade-offs and benefits of beef raised with and without the use of PETs. This review contains a summary of the current literature regarding PET products available. The implications of their use on resource utilization, food safety and security, as well as animal health and welfare are discussed. Furthermore, we identified gaps in knowledge and future research questions related to the sustainability of these technologies in beef production systems. This work highlights the tradeoffs between environmental sustainability of beef and supplying the dietary needs of a growing population.