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Energy balance and macronutrient distribution in relation to C-reactive protein and HbA1c levels among patients with type 2 diabetes

توازن الطاقة وتوزيع المغذيات الكبيرة فيما يتعلق بالبروتين التفاعلي C ومستويات HbA1c بين مرضى السكري من النوع 2
Authors: Hiba Bawadi; Rami Katkhouda; Ahmad A Al-Haifi; Reema Tayyem; Cosette Fakih Elkhoury; Zeina Jamal;

Energy balance and macronutrient distribution in relation to C-reactive protein and HbA1c levels among patients with type 2 diabetes

Abstract

Contexte : Des preuves de plus en plus nombreuses indiquent que l'obésité et le diabète sont des états d'inflammation associés à une circulation élevée de médiateurs inflammatoires.L' adiposité excessive et le stress oxydatif, induits par l'alimentation, peuvent également conduire à un état d'inflammation de bas grade.Objectif : Cette étude visait à étudier le bilan énergétique et la distribution par rapport à l'inflammation de bas grade chez les patients atteints de diabète de type 2.Design : Une étude transversale comprenait 198 patients masculins et féminins atteints de diabète de type 2.Le poids, la taille, le tour de taille, la graisse corporelle totale et le pourcentage de graisse tronculaire des patients, l'énergie et l'apport en macronutriments ont été mesurés.Les échantillons de sang ont été prélevés, et les taux d'HbA1c et les taux sériques de protéine C-réactive de haute sensibilité (hs-CRP) ont été déterminés.Résultats : Après ajustement pour tenir compte des covariables (indice de masse corporelle, graisse corporelle totale et graisse tronculaire), le bilan énergétique était positivement corrélé avec hs-CRP et HbA1c. Un bilan énergétique positif était également associé à une augmentation du tour de taille et du pourcentage de graisse tronculaire (p B0,05) .L' apport énergétique total, le pourcentage d'énergie provenant des graisses (p 00,04) et le pourcentage d'énergie provenant des protéines (p 00,03), mais pas le pourcentage d'énergie provenant des glucides (p 00,12), étaient également corrélés avec des taux de hs-CRP plus élevés chez les patients mal contrôlés sur le plan glycémique. Conclusion : un bilan énergétique positif est associé à des élévations du hs-CRP. Une augmentation de l'apport énergétique et des pourcentages accrus d'énergie provenant des graisses et des protéines sont associés à un hs-CRP élevé chez les patients ayant un mauvais contrôle glycémique.

Antecedentes: La evidencia recientemente creciente indica que la obesidad y la diabetes son estados de inflamación asociados con una circulación elevada de mediadores inflamatorios. El exceso de adiposidad y el estrés oxidativo, inducidos por la alimentación, también pueden conducir a un estado de inflamación de bajo grado. Objetivo: Este estudio tuvo como objetivo investigar el equilibrio y la distribución de energía en relación con la inflamación de bajo grado entre pacientes con diabetes tipo 2. Diseño: Un estudio transversal incluyó a 198 pacientes masculinos y femeninos con diabetes tipo 2. Se midieron el peso, la altura, la circunferencia de la cintura, el porcentaje total de grasa corporal y grasa troncal, la energía y la ingesta de macronutrientes de los pacientes. Se recolectaron muestras de sangre venosa. y se determinaron los niveles de HbA1c y los niveles séricos de proteína C reactiva de alta sensibilidad (hs-CRP) .Resultados: Después de ajustar por covariables (índice de masa corporal, grasa corporal total y grasa troncal), el equilibrio energético se correlacionó positivamente con hs-CRP y HbA1c. Un equilibrio energético positivo también se asoció con un aumento de la circunferencia de la cintura y el porcentaje de grasa troncal (p B0.05). La ingesta total de energía, el porcentaje de energía de la grasa (p 00.04) y el porcentaje de energía de las proteínas (p 00.03), pero no el porcentaje de energía de los carbohidratos (p 00.12), también se correlacionaron con niveles más altos de hs-CRP entre pacientes con control glucémico deficiente.Conclusión: El balance energético positivo se asocia con elevaciones en hs-CRP. El aumento de la ingesta de energía y el aumento de los porcentajes de energía de grasas y proteínas se asocian con niveles elevados de hs-CRP entre pacientes con control glucémico deficiente.

Background: Recently growing evidence indicates that obesity and diabetes are states of inflammation associated with elevated circulation of inflammatory mediators.Excess adiposity and oxidative stress, induced by feeding, may also lead to a state of low-grade inflammation.Objective: This study aimed at investigating energy balance and distribution in relation to low-grade inflammation among patients with type 2 diabetes.Design: A cross-sectional study included 198 male and female patients with type 2 diabetes.Patients' weight, height, waist circumference, total body fat and truncal fat percent, energy, and macronutrient intake were measured.Venous blood specimens were collected, and levels of HbA1c and serum levels of high-sensitivity C-reactive protein (hs-CRP) were determined.Results: After adjusting for covariates (body mass index, total body fat, and truncal fat), energy balance was positively correlated with hs-CRP and HbA1c.A positive energy balance was also associated with increased waist circumference and truncal fat percent (p B0.05).Total energy intake, percent energy from fat (p 00.04), and percent energy from proteins (p 00.03), but not percent energy from carbohydrates (p 00.12), were also correlated with higher hs-CRP levels among poorly glycemic-controlled patients.Conclusion: Positive energy balance is associated with elevations in hs-CRP.Increased energy intake and increased percentages of energy from fat and protein are associated with elevated hs-CRP among patients with poor glycemic control.

معلومات أساسية: تشير الأدلة المتزايدة مؤخرًا إلى أن السمنة ومرض السكري هما من حالات الالتهاب المرتبطة بارتفاع الدورة الدموية للوسطاء الالتهابيين. قد تؤدي السمنة المفرطة والإجهاد التأكسدي، الناجم عن التغذية، إلى حالة من الالتهاب منخفض الدرجة. الهدف: تهدف هذه الدراسة إلى التحقيق في توازن الطاقة وتوزيعها فيما يتعلق بالالتهاب منخفض الدرجة بين مرضى السكري من النوع 2. التصميم: شملت دراسة مستعرضة 198 مريضًا من الذكور والإناث المصابين بداء السكري من النوع 2. تم قياس وزن المرضى وطولهم ومحيط خصرهم وإجمالي الدهون في الجسم ونسبة الدهون الجذعية والطاقة والمغذيات الكبيرة. تم جمع عينات الدم الوريدية، وتم تحديد مستويات HbA1c ومستويات مصل البروتين التفاعلي C عالي الحساسية (hs - CRP). النتائج: بعد ضبط المتغيرات المشتركة (مؤشر كتلة الجسم، إجمالي الدهون في الجسم، والدهون الجذعية)، ارتبط توازن الطاقة بشكل إيجابي مع hs - CRP و HbA1c. كما ارتبط توازن الطاقة الإيجابي بزيادة محيط الخصر ونسبة الدهون الجذعية (p B0.05). كما ارتبط إجمالي استهلاك الطاقة، ونسبة الطاقة من الدهون (p 00.04)، ونسبة الطاقة من البروتينات (p 00.03)، ولكن ليس نسبة الطاقة من الكربوهيدرات (p 00.12)، مع ارتفاع مستويات hs - CRP بين المرضى الذين يعانون من ضعف التحكم في نسبة السكر في الدم. الخلاصة: يرتبط توازن الطاقة الإيجابي بالارتفاعات في hs - CRP. يرتبط زيادة استهلاك الطاقة وزيادة النسب المئوية للطاقة من الدهون والبروتين بارتفاع hs - CRP بين المرضى الذين يعانون من ضعف التحكم في نسبة السكر في الدم.

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571, HbA1c, Epidemiology, Physiology, Nutritional Status, Energy balance, C-reactive protein, Waist, Diabetes mellitus, Endocrinology, Health Sciences, TX341-641, Obesity, Sarcopenia: Definition, Diagnosis, and Implications, Internal medicine, Biology, Body mass index, Inflammation, Global Trends in Obesity and Overweight Research, Ecology, Nutrition. Foods and food supply, Public Health, Environmental and Occupational Health, Type 2 diabetes, energy balance, Type 2 Diabetes, Inflammation and Obesity-Related Metabolic Disorders, hs-CRP, FOS: Biological sciences, Medicine, Glycemic, Original Article, type 2 diabetes

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
6
Top 10%
Average
Average
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